50 Cent has taken shots at some of his fiercest enemies after a former NYPD detective confirmed that the G-Unit boss has never cooperated with the police.

50 posted a video of retired detective Bill Courtney detailing his dealings with the New York Hip Hop scene in the late ’90s and early ’00s.

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In the clip, Courtney says: “50 Cent never cooperated with anybody and I would know if he did. I had the whole music industry investigation business locked down. I knew everybody who was talking to everybody. There was no way he cooperated.

“An incident where he was stabbed or somebody was stabbed, maybe it was [Tony] Yayo, in the studio — he didn’t cooperate on that.

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“And I find it funny that the guys who say he cooperated, namely the Gotti brothers [Irv and Chris], they did more stupid things to bring heat on them and heat on everybody else, using two-way pagers to communicate with people when the information is so easy to get ahold of.”

He added of the Murder Inc. Records co-founders: “They did a lot of dumb things and they messed with the wrong guy. He came back, he’s a fighter. And peopl gotta respect that. Even if they don’t like 50, he didn’t have any cops protecting him.”

50 Cent used the video to take aim at various foes, namely Kenneth “Supreme” McGriff, James “Jimmy Henchman” Rosemond and Damion “World” Hardy.

He wrote in the caption: “See the facts always come out, I wasn’t raised like that. I’m not in Preme, killer Rat ass jimmy, or World’s paper work. Oh yeah all roads lead to Sherevport.”

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It is generally believed that McGriff ordered the murder of 50 Cent when he was shot nine times outside of his grandmother’s house in Queens, New York in 2000.

Supreme was also an associate of the Gotti brothers, whose Murder Inc. label and flagship artist Ja Rule remain bitter rivals of 50’s.

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Hardy is also connected to the “In Da Club” rapper after he was charged with killing Darryl “Hommo” Baum, the former bodyguard of Mike Tyson who is alleged to have fired the nine shots at a young 50.

Hardy, who was killed shortly after the aforementioned shooting, was also linked to a 2003 shooting at a New York hotel that is believed to have targeted 50.

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50 Cent also famously feuded with Jimmy Henchman, who was later sent to prison for ordering the murder of G-Unit associate Lodi Mack.

Fif and Henchman began feuding after The Game was dropped from G-Unit, with the convicted drug trafficker managing the Compton rapper at the time.