50 Cent and Ja Rule‘s long-running feud has reescalated after the latter said he was ready to “go nuclear” on his old enemy over his disrespectful comments about the late Irv Gotti.

Appearing on The Breakfast Club last week, Ja revealed that he was angry about 50 mocking the recent death of his close friend and former Murder Inc. label boss Gotti, but was talked out of responding to him by Kenneth “Supreme” McGriff.

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50 fired back shortly after, posting a clip of Ja’s comments on Instagram and writing: “The Breakfast Club should be ashamed of themselves asking questions that perpetuate violence. This fool has been ready to go what he calls nuclear for 22 years. LOL.”

The G-Unit mogul then further taunted the late Gotti by adding: “Ya man in my Runtz right now!”

50’s sneering post (which has since been deleted) caused Ja Rule to launch into a social media rant in which he rubbished his career, brought up the 2000 attempt on his life and even accused his longtime nemesis of being a snitch.

“@50cent SUCK MY DICK you bitch ass n-gga… I already ate your lunch shut up!!!” he wrote on X. “Until you do something to the n-ggas that shot you you can’t troll no more… [laughing face emoji] handle your business chump lmao…

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He added: “@50cent N-gga you’re a used car salesman everything you do is trash music 1 good album after that trash liquor trash tv shows yeah I said it TRASH how many times you gonna make the same show that coke stepped on parenting trash character trash n-gga you the garbage man… [laughing face emoji].

“From now on your name boo boo that’s what they called you on the streets right lmfao… boo boo the fool… [laughing face emoji] 50 cent is a street n-gga from Brooklyn you boo boo from Queens… Mc gusto cb4 ass n-gga… [laughing face emoji].”

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In response to a fan who argued that 50 Cent “ended Murder Inc.,” Ja hit back: “You’re right he told the Feds murder inc had him shot and they put us under federal indictment… [rat emoji].”

The “Holla” hitmaker then doubled down on his claim by posting alleged paperwork which referred to Curtis Jackson, which is 50’s real name, as an “informant.”

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“@50cent Go ahead and lie tell these good people tell the paperwork fake so I can send this next shot… WE GOT RECEIPTS boo boo…,” Ja wrote.

He also posted screenshots of a HipHopDX article from 2016 about former G-Unit affiliate Bang ‘Em Smurf claiming that 50 sought an order of protection against Murder Inc. following the stabbing of a studio engineer.

“Say I’m lying n-gga I DARE YOU… n-gga said he had to talk yayo out of telling [laughing face emojis] you can’t make this shit up…,” Ja added.

50 Cent has yet to respond to Ja Rule’s rant, although he has previously addressed the allegations that he snitched on Murder Inc.

“They’ll say, ‘He a rat’ or, ‘He this, this and that.’ All you gotta do is ask them who I told on? I ain’t never told on no n-gga in my life,” he said on the Cigar Talk podcast in 2020.

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“In the Preme situation, look at his case. It’ll tell you who told on him. My name ain’t in that case. You see what I’m saying? They tried to use that I needed an order of protection, but why it feels like I’m the bully out here then?

“You needed protection, n-gga. And your protection gone! That’s the truth!” Fif added. “N-ggas will try to put a spin on anything to try to make it look good and then when you get in disputes with younger artists, they don’t know what to use against you so they use what someone else used. So they go back and they go, ‘Oh you this!’”