Floyd Mayweather has set his sights on 50 Cent yet again. This time, the decorated boxing champion explained why he believes Fiddy’s rap career is over in a lengthy Instagram post.

Not only did Mayweather insinuate 50 is a snitch with a carefully placed rat emoji, he also highlighted four specific instances he says killed the Get Rich Or Die Tryin’ mastermind’s career.

“1. You tried desperately to revive your career by going head to head with Kanye West and got dragged publicly, taking a unanimous decision loss,” he wrote on Saturday (August 10). “2. Jay Z been killing the champagne game with Ace of Spade selling worldwide at premium prices for well over a decade, while Curtis got a bottle with a cheap chess piece on it that taste like shampoo.”

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SWIPE LEFT It was only 4 shots that ended Curtis 🐀 Jackson rap career 1. You tried desperately to revive your career by going head to head with Kanye West and got dragged publicly, taking a unanimous decision loss. 2. Jay Z been killing the champagne game with Ace of Spade selling worldwide at premium prices for well over a decade, while Curtis got a bottle with a cheap chess piece on it that taste like shampoo. 3. Beats by Dre headphones was a home run smash, we all know that, but what the fuck was Curtis’s SMS Audio headphones? That was some straight bullshit the FEDs had something to do with. Those are snitch headphones, you can be in your car and hear the people's conversation in the vehicle next to you. 4.Diddy got Ciroc and its still selling worldwide and you can’t find Efen in no stores and it's well known the shit taste like rubbing alcohol.

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Mayweather also said Dr. Dre easily smashed the Power co-founder’s attempt at selling premium headphones — which he referred to as “snitch headphones” — and called 50’s Effen vodka “rubbing alcohol.”

“3. Beats by Dre headphones was a home run smash, we all know that, but what the fuck was Curtis’s SMS Audio headphones? That was some straight bullshit the FEDs had something to do with. Those are snitch headphones, you can be in your car and hear the people’s conversation in the vehicle next to you. 4.Diddy got Ciroc and its still selling worldwide and you can’t find Efen in no stores and it’s well known the shit taste like rubbing alcohol.”

Of course, Fiddy didn’t let Mayweather’s comment slide and took another slick jab at the boxer’s reading abilities.

“Tell Floyd I said he won he is the greatest of all time,” he wrote in the caption. “and nobody I mean nobody can ever take that away from him what he’s done with his life is amazing. I’m done with all of the back and forth.

“Now Can Someone Please Read This To Champ.#POSTIVE VIBES.”

50 clowned Mayweather last month in another Instagram post for flaunting the world’s largest Chanel bag.

“You can have the biggest Chanel in the store if you want it,” he said. “I don’t think Lil Baby was talking about this dumb shit you bought champ. LOL GET THE FUCK OUTTA HERE! #lecheminduroi#bransoncognac Legendary stupid shit.”