2Pac’s still-unsolved murder remains a touchy subject for Duane “Keefe D” Davis, the uncle of the rapper’s alleged killer Orlando Anderson — at least when it comes to one theory surrounding the shooting.

In a new interview clip with The Art of Dialogue that was published on Thursday (July 20), Keefe D struggled to hide his annoyance when he was asked if DeAndre “Dre” Smith was actually the one who fatally shot ‘Pac on September 7, 1996 in Las Vegas.

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Smith was allegedly one of four men in the white Cadillac that pulled up alongside 2Pac and Suge Knight that fateful night. Detectives believe he was sat in the back of the car next to Anderson, the prime suspect in the case.

Keefe D previously admitted that he was also in the vehicle, with the shots being fired “from the backseat.”

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“How do you feel about the people that feel like Big Dre, he shot 2Pac?” the interviewer asked. “‘Cause you did make a confession some years ago and you said that you gave the gun to Big Dre, but he got cold feet so Orlando, he ended up snatching the gun and shooting 2Pac.”

“Nah, big dawg. Nah,” Keefe D responded while throwing his hands up in frustration.

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“Was Big Dre like that? Was he capable of doing that? Was he a shooter?” the interviewer probed.

“Them dudes was kids, man. Both of them dudes was kids back then,” Davis countered. “Dre was an All-CIF basketball player. He had a nice shot, dunking, all that shit. Dre was an athlete. He wasn’t about that.”

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“So he didn’t pull the trigger?” Keefe D was asked once more, to which he replied: “Man! We already discussed that! What, you trying to get me in jail again?!”

The clip then cuts off, ending the tense conversation.

Keefe D’s alleged role in 2Pac’s murder has come back into sharp focus in recent days after Las Vegas police executed a search warrant on the home belonging to his wife on Monday (July 17) as part of the long-dormant investigation into the rapper’s death.

Various items were seized during the search, including computers, hard drives and magazine articles about ‘Pac. They also recovered pictures from the 1990s of individuals who might have been connected to people directly or indirectly involved in the shooting, as well as copies of Davis’ 2019 book Compton Street Legend, in which he discusses 2Pac’s slaying.

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While police viewed the search as a “success,” it remains to be seen whether any of the belongings could present a direct link between the target of the investigation and the 1996 drive-by shooting.

The evidence is now being presented to a Las Vegas grand jury, although a police official said it could take months for the grand jury to decide whether to indict anyone.

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Investigators have long believed that the gunman is likely already dead (Orlando Anderson was killed during an unrelated gang shooting in 1998), but they’re hoping they can at least determine who was in the car when the fatal shots were fired. That could lead to someone being charged as an accomplice.

2Pac’s murder is long believed to have stemmed from an altercation between the rapper, his entourage and Anderson in the lobby of the MGM Grand in Vegas hours before the shooting.

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Anderson, a member of the South Side Compton Crips, was alleged to have stolen the chain of a Death Row Records affiliate months earlier.

He was identified as a suspect soon after the shooting, but denied any involvement and was never charged over the crime. No arrests have ever been made in the case.