50 Cent and Chelsea Handler have not been an item for quite some time — but the comedian is more than happy to use the Power executive producer as cannon fodder for her comedy routines.

Not that Fif necessarily minds.

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In an Instagram post dated Sunday (May 21), the G-Unit head honcho featured a reel of one of Handler’s stand-up routines, in which she goes into detail about the joys of anal sex — and, more specifically, about the joys of anal sex with the “I Like The Way She Do It” rapper.

“Anal sex is not just for homosexual men anymore, okay?” she begins. “Ladies and gentlemen, it’s trending. And don’t knock it until you try it. You might fucking like it.”

She continued: “It’s a big pill to swallow in the beginning but when you warm up to the idea, and you pick the right candidate, you know…small or medium, you’re not going to do that with, like, 50 Cent. You want to pick the right candidate.”

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Fif took the compliment in stride, writing, “Yo she is so crazy, @chelseahandler is hand down the funniest. LOL #bransoncognac #lecheminduroi.”

Back in 2012, Chelsea Handler and 50 Cent were assumed to be in a relationship after the two were pictured kissing one another, but never admitted to an affair until January of that year.

50 Cent Sets Tongues Wagging As Girlfriend Teases Relationship Bombshell
50 Cent Sets Tongues Wagging As Girlfriend Teases Relationship Bombshell

And in what can only be described as a strange turn of events, the reason for the end of their affair involved Ciara.

During an interview with Howard Stern, the TV personality revealed that she was in a relationship with Fif for two months but broke it off after Ciara, who was his former fling, said that she still had feelings for him.

To cut him off, Handler called him “the worst thing you could say to a black person, short of calling him the N-word,” and never spoke to him again.

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Fif never did respond to the comments Handler allegedly made.

But the pair clearly don’t have bad blood between them, because back in 2014, 50 Cent posted a photo of himself with Handler to celebrate the conclusion of her E! talk show, Chelsea Lately.

“I think Chelsea turns me on because she crazier then me lol #SMSaudio,” he wrote in the caption.